NASDAQ: ORKA

Oruka Therapeutics (ORKA) Stock Analysis & Forecast

Sep 28 close

$84.19−0.27 (−0.3%)

Gekko Brief

AI summary

Oruka Therapeutics moved this week on clinical trial news for ORKA-001, its psoriasis drug. The company reported positive week 28 data from the ongoing EVERLAST-A trial, with PASI 100 increasing to 71.4% and PASI 90 to 87.3%, showing deepening responses without additional dosing, and a favorable safety and tolerability profile maintained through week 28. Despite this positive efficacy data, shares fell 5% amid the report, with safety disclosures apparently weighing on the stock even as the underlying trial results were described as positive.

ORKA closed at $84.19, down 0.3%, with the stock sitting between its 50-day average of $96.50 and its 200-day average of $62.87. The GekkoIndex reads 67.9, placing the stock in the Accumulation zone. Price sits 23.4% below Gekko Fair Value of $109.88. The stock's one-month return stands at -12.8%, though its six-month return remains at 89.3% and its one-year return at 459.4%.

Looking ahead, Oruka's next earnings report is scheduled for 11 November 2026, 43 days away, placing it outside a typical 20-trading-day holding window. The prior quarter saw an EPS beat, with actual results of -0.55 against an estimate of -0.49, producing a 5.9% price reaction. Seasonality data shows the next 20 trading days have averaged an 18.6% return over 5 years, though gains occurred in only 2 of those years. Eleven analysts currently rate the stock a buy, with a consensus target of $155.00.

Written by AI and checked automatically against the figures on this page. Generated Sep 29, 2026 from the data above.

Oruka Therapeutics price vs fair value

$109.88$84.19Sep ’25Mar ’26Sep ’26
Close $84.19200-day averageGekko Fair Value $109.88

Oruka Therapeutics quick facts

Market cap
$5.08B
P/E ratio
—
Forward P/E
—
EPS, TTM
−$2.04
Revenue, TTM
$0
Profit margin
0%
Dividend yield
—
Beta
-0.21
Volume
923,248 avg 939,179
1-year return
+459.4%
Typical daily move
±5.6%
Typical 20-day move
±7.5%
50-day average
$96.50
200-day average
$62.87
Next earnings
Nov 11
Shares outstanding
66.21M
52-week range
$15.00$115.52

Oruka Therapeutics swing-trade checklist

Oruka Therapeutics scores 3 supportive, 2 mixed and 0 headwinds across the 5 checklist items with data.

Six things swing traders check before a 20-day hold, read from the latest data.

3 supportive2 mixed0 headwinds

  • Trendmixed

    Averages disagree

    Close $84.19 sits between the 50-day ($96.50) and 200-day ($62.87) averages, or the averages disagree.

    See the chart
  • GekkoIndexsupportive

    67.9, Accumulation

    Reading 67.9 is in the Accumulation zone.

    See the GekkoIndex
  • Fair valuesupportive

    23.4% below

    Price is 23.4% below Gekko Fair Value (more than 5% below).

    See fair value
  • Smart moneyno data

    No data

    No insider, Congress or unusual options activity in the window.

    See smart money
  • Earnings risksupportive

    Reports in 43 days

    Next report Nov 11, 2026, 43 days away — outside a typical 20-trading-day hold.

    See earnings
  • Seasonalitymixed

    +18.6% on average

    From this point in the calendar, the next 20 trading days averaged +18.6% over 5 years, rising in 2 of them.

    See seasonality

A description of current data, not a recommendation. How this page works

Oruka Therapeutics stock chart and price history

Oruka Therapeutics closed at $84.19 on Sep 28, 2026, +459.4% over the past year, inside a 52-week range of $15.00 to $115.52.

Close50-day average200-day averageVolume
Oruka Therapeutics share price, past year, with 50-day and 200-day moving averages and volume$20$40$60$100NovDecJan 2026FebMarAprMayJunJulAugSep84.19

Use the left and right arrow keys to read daily values.

Performance Breakdown

1 month
−12.8%
3 months
−9.0%
6 months
+89.3%
1 year
+459.4%
The full ORKA chart adds GekkoIndex, insider, options, Congress and hedge fund markers, plus TrendCandles™.Open ORKA in Gekko

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About Oruka Therapeutics

Oruka Therapeutics is a clinical-stage biopharmaceutical company working on monoclonal antibody treatments for psoriasis and related inflammatory and immunology conditions. Its work centers on a set of drug candidates aimed at underlying immune pathways linked to these diseases, with the goal of offering new treatment options to patients affected by them.

The company's pipeline includes ORKA-001, aimed at the p19 subunit of interleukin-23 and currently in a phase 2a trial for psoriasis, and ORKA-002, which targets both interleukin-17A and interleukin-17F and is being tested in a phase 2 trial for psoriasis, psoriatic arthritis, and other conditions. It is also developing ORKA-003, aimed at a pathway that has not been disclosed, along with ORKA-021, a regimen that combines ORKA-002 and ORKA-001 in sequence.

Oruka Therapeutics is headquartered in Menlo Park, California, and its shares are listed on the NASDAQ under the ticker ORKA.

Listed
NASDAQ
Sector
Health technology
Industry
Pharmaceuticals: major
Website
orukatx.com

Oruka Therapeutics GekkoIndex: the smart money zone

Oruka Therapeutics’s GekkoIndex — Gekko’s 0 to 100 smart money score — reads 67.9, in the Accumulation zone, up 7.7 points over five sessions.

010067.9Accumulation

Up 7.7 points over five sessions.

Reading for Sep 28, 2026

What followed past readings in each zone

ZoneReadings5 days10 days20 days50 days
Buying41+3.1%+8.7%+3.1%−3.2%
Accumulation (current zone)158+0.4%+0.5%+0.9%−2.8%
Neutral407+2.7%+4.5%+11.0%+35.5%
Distribution56+1.6%+8.2%+13.2%+28.9%
Selling10−7.5%−9.2%−12.0%−8.1%

Average ORKA share-price change over the trading days after each daily reading in its GekkoIndex history. Across every stock Gekko tracks, Accumulation readings averaged +2.3% over 20 days. Past behaviour doesn’t guarantee future results.

Accumulation zone: Institutional interest building. About the five zones →

See every daily GekkoIndex reading plotted over the ORKA price, zone by zone.Track ORKA in Gekko

Is Oruka Therapeutics stock overvalued? Gekko Fair Value

Oruka Therapeutics trades 23.4% below Gekko Fair Value of $109.88, so the shares are undervalued on Gekko’s estimate.

Gekko’s own estimate of what Oruka Therapeutics shares are worth, recalculated every trading day.

$109.88

Gekko Fair Value, Sep 26, 2026

23.4% Undervalued

How Gekko Fair Value works →

Gekko Fair Value on every chart, with the gap to price updating daily.Open ORKA in Gekko

Oruka Therapeutics insider and Congress trading

No open-market insider purchases were filed for Oruka Therapeutics, and no Congress trades were disclosed, in the last 90 days.

Plus buybacks, unusual options and fund positions, each dated to when it became public.

Insider buying last 90 days

No open-market insider purchases were filed for ORKA in the last 90 days.

From Form 4 filings, dated to when each was filed.

Every ORKA insider filing, plotted on the chart in Gekko.Open ORKA in Gekko

Congress trades last 90 days

No trades in ORKA were disclosed by members of Congress in the last 90 days.

From congressional disclosures, which report amounts as ranges.

Congress disclosures for ORKA, plotted on the chart in Gekko.Open ORKA in Gekko

Hedge funds and billionaires quarter ended Jun 30

2of the funds Gekko tracks hold ORKA.

0added1opened1trimmed0sold out
Which funds are on each side, name by name.Unlock in Gekko

Oruka Therapeutics earnings: next date and track record

Oruka Therapeutics reports on Nov 11, 2026 (43 days away), and beat the EPS estimate in 5 of its last 8 reports.

5 of 8reports beat the EPS estimate
±5.9%average move across the report
4 of 8reports followed by a gain

Share-price move across each report

−8.0%Nov ’24+0.8%Mar ’25−1.7%May ’25+6.6%Aug ’25−6.5%Nov ’25+16.2%Mar ’26−1.2%May ’26+5.9%Aug ’26
ReportedEPSSurpriseRevenueSurpriseMove
Aug 10, 2026−$0.55
est −$0.49
−12.2%——+5.9%
May 13, 2026−$0.48
est −$0.54
+11.1%——−1.2%
Mar 12, 2026−$0.45
est −$0.62
+26.9%——+16.2%
Nov 12, 2025−$0.55
est −$0.56
+1.8%——−6.5%
Aug 11, 2025−$0.46
est −$0.48
+4.2%——+6.6%
May 14, 2025−$0.40
est −$0.44
+9.1%——−1.7%
Mar 6, 2025−$0.54
est −$0.41
−31.7%——+0.8%
Nov 13, 2024−$1.46
est −$0.32
−356.2%——−8.0%

“Move” is the close of the first session after the report compared with the close of the last session before it, so it reads the same whether the company reported before the open or after the close.

Oruka Therapeutics stock forecast and analyst price targets

Analysts’ average 12-month price target for Oruka Therapeutics is $155.00, +84.1% from the last close, from 11 firms rating the stock in the last 90 days.

$155.00consensus 12-month target, +84.1% from the last close
Low $120High $200
Buy11
Hold0
Sell0

Each firm’s latest rating in the last 90 days: 11 firms.

Latest analyst actions

DateFirmRatingTargetvs price
Sep 24H.C. WainwrightBuy, reiterated$120+42.5%
Sep 24WedbushBuy, maintained$165+96.0%
Sep 23LifeSci CapitalBuy, maintained$175+107.9%
Sep 23Clear StreetBuy, maintained$131+55.6%
Sep 21BarclaysBuy, maintained$160+90.0%
+0.9%average 20-day move after past Accumulation readings
+18.6%average move over the next 20 trading days in the last 5 years
±5.6%typical daily move, from the 14-day average range

Gekko doesn’t publish price predictions. These are analyst targets and historical base rates, which don’t guarantee future results.

Oruka Therapeutics seasonality: the next 20 trading days

Over the next 20 trading days from Sep 26, Oruka Therapeutics averaged +18.6% across the last 5 years, rising in 2 of them.

Next 20 trading days, by year

−9.1%2021−0.5%2022−2.5%2023+24.4%2024+79.3%2025

Average move and hit rate

WindowAverageYears higher
Next 5 trading days+6.7%3 of 5
Next 10 trading days+14.2%3 of 5
Next 15 trading days+19.4%4 of 5
Next 20 trading days+18.6%2 of 5
Next 30 trading days+15.9%2 of 5

For scale, ORKA’s typical 20-trading-day move in either direction is about 7.5%.

Oruka Therapeutics market cap and key statistics

Oruka Therapeutics’s market cap is $5.08B and revenue of $0 over the last twelve months.

Valuation

Market cap
$5.08B
EPS, TTM
−$2.04
Gekko Fair Value
$109.88

Trading

Volume
923,248
Avg volume, 20 days
939,179
52-week high
$115.52
52-week low
$15.00
Shares outstanding
66.21M

Financials

Revenue, TTM
$0
Profit margin
0%
Return on equity
-18.2%
Quarterly earnings growth, YoY
0.0%

Risk and income

Beta
-0.21
Typical daily move
±5.6%
Typical 20-day move
±7.5%

Oruka Therapeutics stock news this week

3 headlines about Oruka Therapeutics from the past week, newest first, each linking to the publisher.

Oruka Therapeutics peers

Oruka Therapeutics’s 6 largest industry peers by market value, with today’s move, GekkoIndex zone and gap to Gekko Fair Value.

StockTodayGekkoIndex zonevs Fair Value
LLYEli Lilly+0.4%Neutral17.9% above
JNJJohnson & Johnson+0.7%Neutral0.5% above
ABBVAbbVie+0.7%Neutral23.3% above
MRKMerck+0.7%Neutral4.2% below
AZNAstraZeneca+0.3%Neutral39.9% below
PFEPfizer+0.4%Neutral4.0% below

A peer links to its own page where one exists.

In the Buying zone today

Reporting earnings this week

Popular on Gekko

Oruka Therapeutics stock FAQ

What is Oruka Therapeutics’s market cap?

Oruka Therapeutics’s market cap is $5.08B at the Sep 28, 2026 close of $84.19, with 66.21M shares outstanding.

What is the Oruka Therapeutics stock forecast?

The consensus analyst 12-month price target for Oruka Therapeutics is $155.00, +84.1% from the last close. Of the 11 firms that rated the stock in the last 90 days, 11 rate it a buy, 0 a hold and 0 a sell. Gekko doesn’t publish price predictions of its own.

Is Oruka Therapeutics stock overvalued or undervalued?

On Gekko’s estimate Oruka Therapeutics is undervalued: the Sep 28, 2026 close of $84.19 is 23.4% below Gekko Fair Value of $109.88. Gekko Fair Value is recalculated every trading day, and a gap inside 5% either way counts as about fair value.

When does Oruka Therapeutics report earnings next?

Oruka Therapeutics is expected to report on Nov 11, 2026 (43 days away). Analysts expect earnings of −$0.60 per share. Oruka Therapeutics beat the earnings estimate in 5 of its last 8 reports, moving 5.9% on average across the report.

What is Oruka Therapeutics’s 52-week high and low?

Oruka Therapeutics’s 52-week high is $115.52 and its 52-week low is $15.00; it closed at $84.19 on Sep 28, 2026, +459.4% over the past year.

Is Oruka Therapeutics stock a buy right now?

Gekko describes the data; it does not make buy or sell recommendations. On the swing-trade checklist, 3 of the 5 items with data read as supportive (gekkoindex, fair value and earnings risk), 2 as mixed (trend and seasonality). The checklist is a description of current data, not a recommendation.

How this page works

During US trading hours the price at the top of the page is a delayed quote, refreshed every 15 minutes; everything else is rebuilt after each US market close. The GekkoIndex, Gekko Fair Value and the checklist are Gekko’s own, and the Gekko Brief is written by AI from this page’s data and checked against it before it is published. How Gekko’s data works →

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